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Related Concept Videos

Aging01:26

Aging

59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K

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Related Experiment Video

Updated: Jul 12, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

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Biological aging in multiple sclerosis.

Yinan Zhang1, Jeffrey Atkinson1, Christin E Burd2

  • 1Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 25, 2023
PubMed
Summary
This summary is machine-generated.

Aging exacerbates multiple sclerosis (MS) progression, particularly in older adults. Understanding how biological aging interacts with MS pathways is crucial for developing new treatments targeting neurological decline.

Keywords:
Animal modelbiomarkersimmunologymultiple sclerosisoutcome measurementprogressive

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Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Multiple sclerosis (MS) predominantly affects older adults, with increasing prevalence.
  • Progressive MS forms are challenging to treat with current disease-modifying therapies (DMTs).
  • Biological aging mechanisms interacting with MS pathogenesis are not fully understood.

Purpose of the Study:

  • To review the impact of aging biology on multiple sclerosis (MS) pathogenesis.
  • To explore how aging influences disability accumulation in MS.
  • To identify potential therapeutic targets for progressive MS.

Main Methods:

  • Review of current literature on aging biology and MS.
  • Analysis of preclinical models (experimental autoimmune encephalomyelitis - EAE) of MS in aging animals.
  • Examination of age-related biomarkers in individuals with MS.

Main Results:

  • Middle-aged animals in EAE models show more severe and prolonged disease with neuroinflammation.
  • Biomarkers suggest accelerated biological aging in people with MS compared to controls.
  • Distinguishing biological age from chronological age may improve understanding of aging's role in MS.

Conclusions:

  • Aging significantly impacts MS pathogenesis and disease severity.
  • Novel biomarkers and senotherapy agents targeting aging pathways are promising for progressive MS.
  • Further research is needed to develop interventions for age-related neurological decline in MS.