Related Experiment Video
Updated: Jul 12, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Nuclear Receptors-Mediated Endocrine Disrupting Effects of Non-Phthalate Plasticizers: A Review
Jia Yu1, Haoyang Zou1, Tiehua Zhang1
1College of Food Science and Engineering, Jilin University, Changchun 130062, China.
Abstract:
In 2021, the global market for non-phthalate plasticizers reached $3.1 billion, and it is projected to grow by 25.8% by 2025. These plasticizers have gained substantial attention as substitutes for phthalates in various industrial applications due to their potential health and environmental risks, particularly in agroecosystems where they have emerged as contaminants. Furthermore, recent studies have demonstrated that non-phthalate plasticizers can exert endocrine-disrupting effects through mechanisms mediated by nuclear receptors. This review aims to summarize the present understanding of the molecular mechanisms by which non-phthalate plasticizers modulate the activity of nuclear receptors, including estrogen receptor, androgen receptor, glucocorticoid receptor, and peroxisome proliferator-activated receptors. Furthermore, the potential health impacts of exposure to conventional phthalate plasticizers are discussed, with a particular emphasis on developmental and reproductive toxicity, metabolic disorders, and carcinogenesis. Overall, this review underscores the significance of evaluating the endocrine-disrupting effects of non-phthalate plasticizers and lays the foundation for the development of safer alternatives within the plastic industry.
More Related Videos
06:46Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
Published on: June 2, 2023
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Plasticizers
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Internal Receptors
Intracellular Hormone Receptors
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Signal Transduction: Overview
Typically, signal transduction involves three...