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Enhanced Levels of Adiposity, Stretch and Fibrosis Markers in Patients with Coexistent Heart Failure and Atrial

Xiaoran Fu1,2, Diego Iglesias-Álvarez3, Ana García-Campos3,4

  • 1Translational Cardiology Group, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain.

Journal of Cardiovascular Translational Research
|October 25, 2023
PubMed

Insights

Heart failure (HF) and atrial fibrillation (AF) share inflammatory and adiposity markers. Combined HF and AF show elevated stretch and fibrosis markers, suggesting a key role for the adiposity-fibrosis pathway.

Area of Science:

  • Cardiology
  • Biochemistry
  • Pathophysiology

Background:

  • The coexistence of heart failure (HF) and atrial fibrillation (AF) significantly worsens patient prognosis.
  • Understanding the underlying biological mechanisms linking HF and AF is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate inflammation, metabolism, adiposity, and fibrosis markers in epicardial and subcutaneous fat and plasma.
  • To explore the relationship between these markers and the presence of HF and/or AF.

Main Methods:

  • Analysis of multi-markers in fat biopsies and plasma from 185 cardiac surgery patients.
  • Grouping patients based on the presence of HF or AF.
  • Statistical analysis to identify predictors and correlations.

Main Results:

  • Increased plasma adiposity markers were observed in AF patients.
  • Elevated stretch markers correlated with HF.
  • Patients with both AF and HF exhibited higher levels of ANP and GDF-15.
  • Plasma FABP4 emerged as a key HF predictor after excluding AF.
  • Fat biopsies from AF patients revealed an enhanced inflammatory profile.

Conclusions:

  • Higher adiposity markers are associated with AF or HF individually.
  • Increased stretch and fibrosis markers are linked to the combined presence of AF and HF.
  • The adiposity-fibrosis pathway is implicated in the coexistence of HF and AF.

Keywords:
Adipose tissueAtrial fibrillationBiomarkersHeart failure

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