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Updated: Jul 12, 2025
06:29
Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
Published on: January 31, 2025
622
The microbiota and renal cell carcinoma
Ke Wu1,2, Yaorong Li1,2, Kangli Ma1,2
1Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cellular Oncology (Dordrecht, Netherlands)
|October 25, 2023
Summary
The gut microbiome plays a key role in renal cell carcinoma (RCC) development and treatment. Modulating these microbial communities offers new avenues for RCC diagnosis and therapy.
Area of Science:
- Oncology
- Microbiology
- Genitourinary Medicine
Background:
- Renal cell carcinoma (RCC) represents a significant global health burden, accounting for 2% of all cancer cases.
- Emerging research highlights the crucial involvement of microbial populations in RCC pathogenesis, progression, and therapeutic response.
- Microorganisms influence renal physiology and pathology by modulating host immunity, metabolism, and drug interactions.
Purpose of the Study:
- To review the multifaceted roles of the microbiota in renal cell carcinoma (RCC).
- To explore mechanisms of microbiota-driven carcinogenesis in RCC.
- To discuss the potential of microbiota as biomarkers and therapeutic targets for RCC.
Main Methods:
- Literature review of recent studies on microbiota and RCC.
- Analysis of mechanisms linking microbial communities to RCC development and progression.
- Evaluation of microbiota's potential in diagnostics and therapeutics for RCC.
Main Results:
- Microbiota are implicated in RCC oncogenesis, tumor growth, and response to anticancer treatments.
- Microbial metabolites and interactions can influence host immune responses and metabolic pathways relevant to RCC.
- Microbiota hold promise as screening, prognostic, and predictive biomarkers for RCC.
- Microbiota manipulation strategies may enhance anticancer drug efficacy and reduce treatment side effects.
Conclusions:
- The gut microbiome significantly impacts renal cell carcinoma (RCC) development and response to therapy.
- Microbiota offer potential as novel biomarkers for RCC diagnosis and prognosis.
- Targeting the microbiota presents a promising strategy for innovative RCC prevention and treatment approaches.
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