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Improving Mild to Moderate Depression With an App-Based Self-Guided Intervention: Protocol for a Randomized

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This study evaluates a transdiagnostic app for mild to moderate depression, aiming to improve symptoms and quality of life. The digital intervention shows promise for scalable mental health treatment.

Keywords:
depressiondigital appdigital interventione-mental healthinterventionmHealthmental healthmobile appmobile healthmobile phonepublic healthrandomized controlled trialself-managementtransdiagnosticunguidedunguided digital intervention

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Area of Science:

  • Digital Health
  • Psychiatry
  • Mental Health Interventions

Background:

  • Depression is a prevalent mental disorder often co-occurring with others, with over 80% not receiving specialized treatment.
  • Self-guided digital interventions offer scalable solutions for public health, with transdiagnostic approaches showing promise.
  • Current digital tools often focus on specific disorders, highlighting the need for broader applicability.

Purpose of the Study:

  • To assess the efficacy of a self-guided transdiagnostic app-based intervention for mild to moderate depression.
  • To investigate the intervention's impact on depression symptoms, quality of life, anxiety, and self-management skills.
  • To evaluate the intervention in patients with and without comorbid mental disorders.

Main Methods:

  • A randomized controlled trial involving up to 570 adult patients with mild or moderate depression.
  • Intervention group receives the 'MindDoc with Prescription' app alongside usual care; control group receives usual care only.
  • Data collection at baseline, 8 weeks, and 6 months, with depression symptom severity as the primary outcome.

Main Results:

  • Recruitment began February 2023; as of September 2023, 275 participants were enrolled.
  • 176 participants have provided primary outcome data, with approximately 20% missing values.
  • The trial is ongoing, with data analysis planned to assess intervention efficacy.

Conclusions:

  • The study will determine if the transdiagnostic digital intervention improves depression symptoms in individuals with mild to moderate depression.
  • Findings will contribute to the evidence base for transdiagnostic digital mental health interventions.
  • The research aims to enhance patient empowerment and self-management skills through accessible digital tools.