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Development of a Speech-based Composite Score for Remotely Quantifying Language Changes in Frontotemporal Dementia.

Jessica Robin¹, Mengdan Xu¹, Liam D Kaufman¹

¹Winterlight Labs, Incorporated, Toronto, Ontario, Canada.

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology

|October 25, 2023

Summary

Speech and language decline in frontotemporal dementia (FTD) can be tracked using novel remote digital assessments. A new composite score effectively measures this decline, aiding in disease monitoring and treatment response detection.

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Area of Science:

Neurology
Speech-Language Pathology
Biomedical Engineering

Background:

Speech and language changes are hallmark symptoms across frontotemporal dementia (FTD) subtypes.
These communication impairments significantly impact daily functioning and quality of life.
Accurate assessment is crucial for monitoring disease progression and treatment efficacy.

Purpose of the Study:

To identify specific speech and language features that change over time in individuals with FTD.
To develop and validate a novel composite score for tracking speech and language decline in FTD.
To explore the utility of remote digital speech assessments for FTD evaluation.

Main Methods:

Recruitment of individuals with FTD for remote digital speech assessments using a picture description task.
Analysis of speech samples to extract acoustic and linguistic measures.
Longitudinal testing of identified measures for change over time and computation of a novel composite score.

Main Results:

Eight language variables demonstrated significant longitudinal decline across FTD subtypes.
A novel composite score, derived from these variables, showed significant change over time.
The composite score exhibited high test-retest reliability and correlated with established speech task measures.

Conclusions:

Remote digital speech assessments offer a viable method for characterizing FTD-related speech and language changes.
This approach reduces the burden of in-person clinical evaluations.
The developed composite score provides a sensitive and functionally relevant measure for FTD research and clinical practice.