Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics

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Updated: Jul 12, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.0K

Saranya P Wyles1, Jean D Carruthers2, Parisa Dashti1

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.

Gerontology
|October 25, 2023
PubMed
Abstract

Insights

Cellular senescence, a key aging factor, affects skin cells like melanocytes and fibroblasts. Targeting these senescent cells offers potential for improving skin aging and optimizing aesthetic procedures.

Area of Science:

  • Dermatology
  • Gerontology
  • Cell Biology

Background:

  • Skin aging is characterized by cellular dysfunction and extracellular matrix degradation, leading to visible signs like wrinkles and altered pigmentation.
  • Intrinsic and extrinsic factors accelerate skin aging, impacting its structure and function.
  • Treatments for age-related skin changes aim to enhance skin appearance and health.

Purpose of the Study:

  • To review skin aging mechanisms, focusing on cellular senescence.
  • To explore senolytic interventions for targeting senescent cells in the skin.
  • To enhance understanding of age-related skin changes and optimize aesthetic outcomes.

Main Methods:

  • Literature review on skin aging and cellular senescence.
  • Analysis of cellular senescence markers in epidermal and dermal skin cells.
  • Discussion of senolytic agents and their potential application in dermatology.

Main Results:

  • Cellular senescence is a significant hallmark of skin aging, affecting both epidermal (melanocytes) and dermal (fibroblasts) cells.
  • Senescent cells exhibit resistance to apoptosis and possess a distinct secretory phenotype.
  • Senescent cells contribute to the macroscopic signs of skin aging.

Conclusions:

  • Understanding skin-specific senescent cells is crucial for addressing age-related skin changes.
  • Senolytic interventions hold promise for selectively eliminating senescent cells and mitigating skin aging.
  • Targeting cellular senescence may offer novel strategies for improving skin health and aesthetic outcomes.
Keywords:
Age-related changesCellular senescenceDermal senescenceEpidermal senescenceSkin aging

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