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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Related Experiment Video

Updated: Jul 12, 2025

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
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Bioengineered nanotechnology for nucleic acid delivery.

Yang Zhang1, Jing Luo2, Xiran Gui3

  • 1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 25, 2023
PubMed
Summary

Bioengineered nanocarriers offer advanced nucleic acid delivery for treating diseases like cancer. This review highlights exosomes, protein nanocages, and other nanocarriers, discussing their potential and challenges for clinical use.

Keywords:
Bioengineered nanotechnologyCell membrane-derived nanovesicleExosomeNucleic acid deliveryProtein nanocageVirus-like particle

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Therapeutics

Background:

  • Nucleic acid-based therapies show promise for genetic disorders, cancers, and viral infections.
  • Existing delivery systems like lipid nanoparticles have achieved clinical success.
  • Bioengineered nucleic acid delivery nanocarriers are gaining attention for their design flexibility and biocompatibility.

Purpose of the Study:

  • To review recent advancements in bioengineered nucleic acid delivery nanocarriers.
  • To focus on exosomes, cell membrane-derived nanovesicles, protein nanocages, and virus-like particles.
  • To discuss their features, advantages, applications, and challenges for clinical translation.

Main Methods:

  • Literature review of recent advances in bioengineered nanocarriers for nucleic acid delivery.
  • Analysis of unique features, advantages, and biomedical applications of specific nanocarrier types.
  • Discussion of challenges and future directions for clinical translation.

Main Results:

  • Exosomes, cell membrane-derived nanovesicles, protein nanocages, and virus-like particles are key bioengineered nanocarriers.
  • These nanocarriers offer unique features and advantages for nucleic acid delivery.
  • Their biomedical applications are expanding, but clinical translation faces hurdles.

Conclusions:

  • Bioengineered nanocarriers hold significant potential for advancing nucleic acid therapy.
  • Further development is needed to overcome challenges in clinical translation.
  • This field represents a promising frontier in nanotechnology for medicine.