Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Filling the Void: Rapid Revascularization via Vasculogenic Assembly in Semi-synthetic Granular Hydrogel Grafts.

bioRxiv : the preprint server for biology·2026

Same author

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro-Inflammatory Endothelial Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.

Biomechanics and modeling in mechanobiology·2026

Same author

Evaluating constrained and unconstrained mixture frameworks for predicting engineered heart tissue mechanics.

Acta biomaterialia·2026

Same author

Beyond Histology: A Validated CUBIC-Based Workflow for Volumetric Analysis of Follicles and Cortical Vasculature in Human Ovarian Tissue.

bioRxiv : the preprint server for biology·2026

Same author

Identification of the Unloaded Heart Configuration Including External Interactions.

Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference)·2026

Same journal

Thermoresponsive hydrogel for long-acting delivery of structurally intact and biologically active Fab fragment and monoclonal antibody.

Acta biomaterialia·2026

Same journal

Cell crowding initiates tumor invasion by triggering a nanoscale topography transition of plasma membranes.

Acta biomaterialia·2026

Same journal

Mechanical properties, polymerization, and humidity effects on the egg glue of the Southern green stink bug, Nezara viridula L. (Hemiptera: Pentatomidae).

Acta biomaterialia·2026

Same journal

Hierarchical dual-conductive networks enable high-cell-density spheroid bioprinting for volumetric muscle loss repair.

Acta biomaterialia·2026

Same journal

A flap mechanics testbed for skin reconstructive surgery: Evaluating the mechanical interaction between flap design and anisotropy.

Acta biomaterialia·2026

Same journal

Diabetes Alters Protein Corona to Reprogram Wear Particle-Cell Interaction.

Acta biomaterialia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 12, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

A data-driven computational model for engineered cardiac microtissues.

Javiera Jilberto¹, Samuel J DePalma¹, Jason Lo¹

¹Department of Biomedical Engineering, University of Michigan, MI, USA.

Acta Biomaterialia

|October 25, 2023

Summary

This summary is machine-generated.

Computational models of engineered heart tissues (EHTs) reveal how mechanical forces influence cardiomyocyte maturation. This research enhances our understanding of EHT mechanobiology for improved cardiac tissue engineering.

Keywords:

Cardiac biomechanics Computational modeling Engineered heart tissues Mechanobiology

More Related Videos

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Related Experiment Videos

Last Updated: Jul 12, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Area of Science:

Biomedical Engineering
Cardiovascular Research
Computational Biology

Background:

Engineered heart tissues (EHTs) show promise for heart disease treatment, but achieving mature, adult-like cardiac tissue is challenging.
Mechanical stimuli improve EHT function and cardiomyocyte (CM) maturation, yet the underlying mechanobiology is not fully understood.

Purpose of the Study:

To develop a tissue-specific computational modeling pipeline for EHTs using experimental data.
To investigate the influence of mechanical environments on EHT function and CM maturation.

Main Methods:

Leveraged experimental data from a mechanically tunable setup to create image-based computational models of EHTs.
Incorporated ECM and myofibrillar structure, and functional parameters estimated from experimental data.
Estimated CM active stresses and dissected contributions of myofibrils and ECM to tissue force output.

Main Results:

Significant differences in experimental forces were explained by varying levels of myofibril formation in CMs across different mechanical environments.
Active stress in CMs showed more moderate variations compared to overall tissue force.
The model successfully dissected the relative contributions of myofibrils and ECM to tissue force generation.

Conclusions:

Tissue-specific computational modeling is crucial for augmenting EHT experiments and providing deeper insights into EHT mechanobiology.
Combining in-silico and in-vitro approaches enhances understanding of the biomechanical mechanisms driving EHT development and function.