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Ozanimod-exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histological
Nathaniel A Cohen1, Christopher R Weber2, Jason X Cheng2
1Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL, USA.
Journal of Crohn'S & Colitis
|October 25, 2023
Summary
Ozanimod treatment in ulcerative colitis patients showed unique lymph node changes, including dilated sinuses and sinus histiocytosis. These findings suggest incomplete lymphocyte egress blockage in severe disease.
Area of Science:
- Immunology
- Gastroenterology
- Pathology
Background:
- Ozanimod modulates lymphocyte circulation from lymphoid organs.
- Histological effects of ozanimod on lymph nodes are not well-documented.
Purpose of the Study:
- To investigate lymph node histological changes in ulcerative colitis patients treated with ozanimod.
- To compare these changes with a control group of ulcerative colitis patients.
Main Methods:
- Retrospective analysis of lymph node histology from colectomy specimens.
- Inclusion of ozanimod-treated and untreated ulcerative colitis patients.
- Pathological scoring of specific histological features.
Main Results:
- Ozanimod-treated patients exhibited significantly increased sinus dilation and sinus histiocytosis.
- A trend towards Castleman-like hyperplasia and increased plasma cell infiltration was observed.
- These changes correlate with ozanimod's mechanism of action.
Conclusions:
- Ozanimod induces distinct lymph node histological alterations in ulcerative colitis.
- Observed changes suggest potential limitations in blocking lymphocyte egress in severe cases.
- Further investigation into Castleman-like features is warranted.
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