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[Local corticoid therapy in pediatrics].

R T Rieder

    Fortschritte Der Medizin
    |June 28, 1979
    PubMed
    Summary
    This summary is machine-generated.

    A new hydrocortisone-17-butyrate cream (Alfason) showed excellent results in treating childhood skin conditions. In a double-blind trial, it proved as effective as a fluorinated corticosteroid with a favorable side effect profile.

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    Area of Science:

    • Dermatology
    • Pediatrics
    • Pharmacology

    Background:

    • Hydrocortisone-17-butyrate is a novel ester of hydrocortisone.
    • Corticosteroid-requiring dermatoses are common in childhood.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Alfason (hydrocortisone-17-butyrate) in pediatric patients.
    • To compare Alfason with a commonly prescribed fluorinated corticosteroid.

    Main Methods:

    • An initial open-label trial with 100 children.
    • A subsequent double-blind trial involving 100 children comparing Alfason to a fluorinated corticoid.

    Main Results:

    • Over 90% of patients in both treatment groups showed good to very good effects.
    • No statistically significant differences in efficacy were observed between Alfason and the fluorinated corticoid.

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  • Alfason demonstrated a favorable success-to-side-effect ratio.

    • Conclusions:

    • Alfason is a safe and effective treatment option for pediatric dermatoses.
    • The favorable side effect profile supports the recommendation of Alfason for childhood skin conditions requiring corticosteroid treatment.