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Updated: Jul 12, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Artificial Intelligence, Computational Simulations, and Extended Reality in Cardiovascular Interventions
Saurabhi Samant1, Jules Joel Bakhos1, Wei Wu1
1Center for Digital Cardiovascular Innovations, Division of Cardiovascular Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA; Cardiovascular Biology and Biomechanics Laboratory (CBBL), Cardiovascular Division, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Abstract:
Artificial intelligence, computational simulations, and extended reality, among other 21st century computational technologies, are changing the health care system. To collectively highlight the most recent advances and benefits of artificial intelligence, computational simulations, and extended reality in cardiovascular therapies, we coined the abbreviation AISER. The review particularly focuses on the following applications of AISER: 1) preprocedural planning and clinical decision making; 2) virtual clinical trials, and cardiovascular device research, development, and regulatory approval; and 3) education and training of interventional health care professionals and medical technology innovators. We also discuss the obstacles and constraints associated with the application of AISER technologies, as well as the proposed solutions. Interventional health care professionals, computer scientists, biomedical engineers, experts in bioinformatics and visualization, the device industry, ethics committees, and regulatory agencies are expected to streamline the use of AISER technologies in cardiovascular interventions and medicine in general.
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