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Related Experiment Videos

[Experimental pancreas transplantation].

W Meyer

    Fortschritte Der Medizin
    |August 2, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Pancreatic transplantation in dogs showed initial exocrine hypofunction but gradual recovery. Rejection was indicated by hyperglycemia and low insulin, with immunosuppression slightly extending survival.

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    Area of Science:

    • Veterinary Surgery
    • Transplantation Immunology
    • Endocrinology

    Background:

    • Pancreatic transplantation is a complex procedure with challenges in both autotransplantation and allotransplantation.
    • Understanding the functional recovery and rejection criteria is crucial for successful outcomes.

    Purpose of the Study:

    • To evaluate the functional outcomes of pancreatic auto- and allotransplantation in a canine model.
    • To identify reliable indicators of pancreatic graft viability and rejection.

    Main Methods:

    • Successful canine pancreatic tail auto- and allotransplantation were performed.
    • Functional assessment included glucose tolerance tests, tolbutamide response, and hormonal/enzymatic level monitoring.
    • Pancreas preservation involved a 3-hour perfusion with a membrane oxygenator and pulsatile pump.

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  • Immunosuppression with Imuran (6 mg/kg) was administered to the allotransplantation group.

    • Main Results:

    • Pancreatic autotransplantation initially caused exocrine hypofunction, with normal recovery by 3 months.
    • Tolbutamide prolonged hypoglycemia, and glucose tolerance remained normal post-autotransplantation.
    • Immunosuppression slightly extended survival in allotransplantation.
    • Hyperglycemia, poor islet response to glucose, low plasma insulin, and low amylase levels indicated rejection.
    • Insulin output and pancreatic secretion post-stimulation were reliable indicators of pancreas viability.
    • Oxygen consumption during perfusion was measured as an indicator of viability.

    Conclusions:

    • Pancreatic autotransplantation leads to transient exocrine hypofunction with eventual recovery.
    • Denervation and lymphatic interruption have a transient impact on pancreatic function.
    • Specific metabolic and hormonal markers reliably indicate pancreatic graft rejection.
    • Perfusion parameters and functional tests are key to assessing pancreas viability.