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Gut microbiota and autism spectrum disorders: where do we stand?
Sa'ed H Zyoud1,2, Muna Shakhshir3, Amani S Abushanab4
1Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, 44839, Nablus, Palestine. saedzyoud@yahoo.com.
Gut Pathogens
|October 26, 2023
Summary
Research on gut microbiota and autism spectrum disorder (ASD) is rapidly growing, with studies focusing on gut bacteria modulation as a potential therapy for ASD. This field shows significant promise for future therapeutic interventions.
Area of Science:
- Microbiome research
- Neurodevelopmental disorders
- Pediatric health
Background:
- Children with autism spectrum disorder (ASD) frequently experience digestive issues and gut microbial imbalances.
- These gastrointestinal conditions may contribute to the development of ASD.
- Bibliometric analysis of Scopus-indexed research explores the gut microbiota-ASD connection.
Purpose of the Study:
- To analyze the current research landscape on gut microbiota and ASD.
- To identify key research trends, influential countries, and institutions.
- To pinpoint potential future research directions in this emerging field.
Main Methods:
- Bibliometric analysis of 958 articles from the Scopus database (2003-2022).
- Utilized VOSviewer for visualizing international collaboration and research hotspots.
- Included reference citation analysis to assess research impact.
Main Results:
- Publication output on gut microbiota and ASD surged post-2013, peaking in 2022.
- The United States led in publications, followed by China and Italy, with significant international collaboration.
- Key research themes include gut microbiota modulation for ASD therapy and gut-brain axis dysfunction in ASD.
Conclusions:
- The study of gut microbiota in relation to ASD is a rapidly expanding and significant area of research.
- Findings provide a comprehensive overview of the knowledge landscape and highlight promising future research avenues.
- Increased investment in exploring the therapeutic potential of modulating intestinal microbiota in children with ASD is recommended.
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