Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

696
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
696
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

276
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
276

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Cognitive Behavioral Therapy for Worry Versus Befriending Therapy in Individuals with Persecutory Delusions: A Randomized Trial.

Schizophrenia bulletin open·2026
Same author

Is correction for gradient nonlinearity necessary in a brain diffusion tensor MRI clinical study?

PloS one·2026
Same author

Longitudinal associations between volatility priors and delusions in individuals recovering from an acute psychotic episode.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Charting Cervical Spinal Cord Morphometry Across the Lifespan.

bioRxiv : the preprint server for biology·2026
Same author

Brain functional connectivity patterns associated with adiposity in schizophrenia.

Psychiatry research. Neuroimaging·2026
Same author

The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI.

Epilepsia·2026

Related Experiment Video

Updated: Jul 12, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K

Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.

Suzanne N Avery1, Baxter P Rogers2, Maureen McHugo1

  • 1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

Biological Psychiatry Global Open Science
|October 26, 2023
PubMed
Summary

Early psychosis is linked to elevated functional connectivity in the core hippocampal-medial temporal lobe cortex network. This hyperconnectivity normalizes over time and may indicate early schizophrenia markers.

Keywords:
Functional connectivityGraph theoryHyperconnectivityMedial temporal lobeResting-state fMRISchizophrenia

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.7K
Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

1.5K

Related Experiment Videos

Last Updated: Jul 12, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.7K
Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

1.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Hippocampal abnormalities are consistently observed in schizophrenia.
  • While chronic schizophrenia shows reduced hippocampal volume and function, early stages present mixed findings regarding functional connectivity.
  • This study investigates changes in hippocampal network connectivity in early psychosis.

Purpose of the Study:

  • To test the hypothesis that hippocampal network connectivity is reduced in early psychosis and worsens over two years.
  • To analyze longitudinal resting-state functional connectivity in individuals with early psychosis and healthy controls.

Main Methods:

  • Examined longitudinal resting-state functional connectivity in 140 participants (68 early psychosis, 72 controls).
  • Quantified hippocampal network connectivity at two levels: core hippocampal-medial temporal lobe cortex (MTLC) and extended hippocampal-cortical networks.
  • Utilized graph theory and linear mixed effects models to analyze group and time effects.

Main Results:

  • Early psychosis patients exhibited elevated functional connectivity within the core hippocampal-MTLC network.
  • No significant alterations were found in the broader hippocampal-cortical network.
  • Hippocampal-MTLC network hyperconnectivity normalized over time and predicted improvement in positive symptoms.

Conclusions:

  • Abnormally elevated functional connectivity in the core hippocampal-MTLC network characterizes early psychosis.
  • This localized hyperconnectivity may serve as a marker for the early stages of schizophrenia.
  • Findings suggest potential prognostic and therapeutic implications of hippocampal-MTLC hyperconnectivity.