LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials

Area of Science:

• Molecular biology
• Dermatology
• Genetics

Background:

• Skin aging involves intrinsic and extrinsic factors, with limited understanding of its molecular mechanisms.
• Competing endogenous RNA (ceRNA) networks, regulating gene expression via miRNA competition, are emerging as key players.
• Existing research highlights ceRNA roles in skin aging and wound healing, but a comprehensive overview is needed.

Purpose of the Study:

• To review and synthesize current knowledge on ceRNA networks in skin aging and wound healing.
• To identify specific ceRNA interactions and their roles in these processes.
• To highlight the potential of ceRNA networks as therapeutic targets in dermatology.

Main Methods:

• Literature review of studies investigating ceRNA networks in skin aging and wound healing.
• Analysis of identified ceRNA interactions, including specific RNAs, miRNAs, and target genes.
• Bioinformatic approaches used to predict and validate ceRNA networks.

Main Results:

• Several ceRNA networks implicated in skin aging, such as RP11-670E13.6-miR-663a-CDK4/CD6, Meg3-miR-93-5p-epiregulin, H19-miR-296-5p-IGF2, and PVT1-miR-551b-3p-AQP3.
• ceRNA networks involved in wound healing, including MALAT1-miR-124, H19, and SAN-miR-143-3p-ADD3.
• Identification of critical genes and compounds for skin aging interventions through bioinformatics.

Conclusions:

• ceRNA networks are crucial for understanding the molecular basis of skin aging and wound healing.
• These networks offer promising therapeutic strategies for dermatological conditions.
• Further research into ceRNA mechanisms can advance regenerative medicine and anti-aging therapies.