Dehydroabietane-type bifunctional organocatalysts in asymmetric synthesis: recent progress
Zhen-Wei Zhang1,2, Shao-Wu Liu1, Hong-Ping Huang1
1College of Pharmacy, Guangxi University of Chinese Medicine, Guangxi Zhuang Yao Medicine Center of Engineering and Technology Nanning 530200 China zhenweizhang@gxtcmu.edu.cn dengyanqiu0501@163.com linning@gxtcmu.edu.cn.
Abstract:
Dehydroabietane-type bifunctional organocatalysts derived from rosane-type diterpenes of dehydroabietic acid (DHAA) and dehydroabietylamine (DA) have been utilized in a wide variety of highly enantioselective reactions. Since one well-documented review exclusively reported on the development of terpene-derived bifunctional thioureas in asymmetric organocatalysis in 2013, fragmentary progress on the dehydroabietane-type bifunctional thioureas and squaramides has been mentioned in other reviews. In this mini-review, we systematically analyze and reorganize the published literature on dehydroabietane-type bifunctional organocatalysts in the recent decade according to the type of catalysts. Our aim is for this review to provide helpful research information and serve as a foundation for further design and application of rosin-based organocatalysts.
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