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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian

Wanli Sun1, Fan Yang1, Yiyuan Yang1

  • 1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Frontiers in Genetics
|October 26, 2023
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Summary
This summary is machine-generated.

This Mendelian randomization study reveals obstructive sleep apnea (OSA) causally impacts left ventricular structure and function. The findings suggest OSA is a risk factor for cardiovascular disease by affecting cardiac function.

Keywords:
Mendelian randomizationgenetic associationleft ventricularobstructive sleep apnearight ventricular

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Area of Science:

  • Cardiology
  • Genetics
  • Sleep Medicine

Background:

  • Observational studies indicate a link between obstructive sleep apnea (OSA) and ventricular dysfunction.
  • Conventional studies face limitations like confounding and causal reversal, hindering definitive conclusions.

Purpose of the Study:

  • To investigate the potential causal relationship between obstructive sleep apnea (OSA) and left and right ventricular (LV, RV) structure and function.
  • To overcome limitations of observational studies using a bidirectional, two-sample Mendelian randomization approach.

Main Methods:

  • Utilized summary data from genome-wide association studies for OSA (FinnGen) and cardiovascular magnetic resonance data for LV/RV function (UK Biobank).
  • Employed inverse variance weighted (IVW) as the primary analysis method, supplemented by MR-Egger and weighted median methods.
  • Conducted sensitivity analyses including MR-Egger intercept, Cochran Q statistic, MR-PRESSO, and leave-one-out analysis to assess heterogeneity and pleiotropy.

Main Results:

  • Genetically predicted OSA was found to be causative for increased LV end-diastolic volume and LV stroke volume.
  • Genetically predicted LV ejection fraction was associated with an increased risk of OSA.
  • No significant association was observed between OSA and any right ventricular (RV) parameters.

Conclusions:

  • The genetic analysis supports a potential causal link between obstructive sleep apnea (OSA) and left ventricular structure and function.
  • These findings enhance understanding of OSA as a cardiovascular disease risk factor by demonstrating a direct impact on cardiac structure and function.