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Updated: Jul 12, 2025
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in
Aasif Khan1, Vinod Kumar Meena1, Akshay Silswal1
1Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, India. akoner@iiserb.ac.in.
Abstract:
Peroxynitrite (ONOO-), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO-. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO-. Moreover, PMI-BE also detects endogenously generated ONOO- in live cells.
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