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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Age of Pediatric Patients Affects Delayed Chemotherapy-Induced Vomiting

Hangyan Zhao1, Jianbin Weng2, Wujie Shi2

  • 1Department of Nursing, The Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Clinical Pediatrics
|October 26, 2023
PubMed

Insights

Older children are at higher risk for delayed chemotherapy-induced vomiting (DCIV). This study identified age as a key factor, with older pediatric oncology patients experiencing more severe vomiting episodes.

Area of Science:

  • Pediatric Oncology
  • Clinical Pharmacology

Background:

  • Delayed chemotherapy-induced vomiting (DCIV) is a significant challenge in pediatric cancer care.
  • Identifying risk factors is crucial for improving antiemetic strategies and patient quality of life.

Purpose of the Study:

  • To investigate the independent risk factors associated with delayed chemotherapy-induced vomiting (DCIV) in pediatric oncology patients.
  • To analyze the relationship between patient demographics, clinical features, and the occurrence of DCIV.

Main Methods:

  • A retrospective analysis of pediatric oncology patients from a tertiary care hospital in an Asian urban center.
  • Univariate analysis and logistic regression were employed to identify risk factors.
  • Patients were stratified into high-risk and low-risk groups based on age using the Youden index.

Main Results:

  • Univariate analysis revealed significant associations between DCIV and the number of chemotherapy days, pH, and blood glucose levels.
  • Logistic regression identified patient age as an independent risk factor for DCIV (OR = 1.013, 95% CI = 1.005-1.021, P = .002).
  • Children in the high-risk age group experienced a higher grade of vomiting (P < .05).

Conclusions:

  • Patient age is a significant and independent risk factor for delayed chemotherapy-induced vomiting in pediatric oncology.
  • Older children are more prone to experiencing more frequent and severe episodes of DCIV.
  • These findings highlight the need for age-specific antiemetic management in pediatric cancer patients.

Keywords:
agedelayed chemotherapy–induced vomitingmalignant tumorpediatric patients

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