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Updated: Jul 12, 2025
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Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
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Drug-induced sudden dysphagia.
Celia Gutiérrez Holanda1, Fernando Berdugo Hurtado2, Pilar Martínez Tirado3
1Aparato Digestivo, Hospital Universitario Clínico San Cecilio, España.
Revista Espanola De Enfermedades Digestivas
|October 26, 2023
Summary
Doxycycline, an antibiotic, can cause esophageal damage like esophagitis and ulcers if not taken with enough water or when lying down soon after. This occurs due to its acidic nature and prolonged contact with the esophageal lining.
Area of Science:
- Pharmacology
- Gastroenterology
- Infectious Diseases
Background:
- Doxycycline is a widely prescribed bacteriostatic antibiotic belonging to the tetracycline class.
- It is indicated for treating various infections, including skin and soft tissue infections.
Observation:
- Doxycycline's acidic properties can lead to mucous membrane damage, acting as a caustic agent.
- Inappropriate administration, such as with insufficient fluids or immediately before recumbency, prolongs esophageal contact time.
Findings:
- Prolonged esophageal contact with doxycycline capsules can result in esophagitis-type lesions.
- Ulcerations in the esophagus are a potential consequence of this caustic effect.
Implications:
- Highlights the importance of proper medication administration techniques for doxycycline.
- Informs clinical practice regarding the prevention of drug-induced esophageal injury.
- Emphasizes patient education on safe antibiotic intake to avoid adverse gastrointestinal effects.
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