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Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: Jul 12, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Macrostructural Cerebellar Neuroplasticity Correlates With Motor Recovery After Stroke.

Takashi Hanakawa^1,2,3, Fujiko Hotta³, Tatsuhiro Nakamura^1,2

¹Department of Integrated Neuroanatomy and Neuroimaging, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Neurorehabilitation and Neural Repair

|October 26, 2023

Summary

Stroke survivors show varying motor recovery. This study found that changes in gray matter volume (GMV) in the cerebellum correlate with motor function recovery after stroke, suggesting neuroplasticity plays a key role.

Keywords:

MRI gray matter volume hemiparesis rehabilitation voxel-based morphometry

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Published on: July 10, 2014

Structured Motor Rehabilitation After Selective Nerve Transfers

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

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Last Updated: Jul 12, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

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Published on: February 22, 2020

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Structured Motor Rehabilitation After Selective Nerve Transfers

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Motor recovery after stroke is highly variable, necessitating improved rehabilitation strategies.
Individual differences in motor recovery may be linked to macrostructural neuroplasticity within the motor control network, including the cerebellum.

Purpose of the Study:

To investigate macrostructural neuroplasticity following stroke.
To examine the relationship between gray matter volume (GMV) changes and motor recovery.
To explore the role of the cerebellum in post-stroke motor rehabilitation.

Main Methods:

Utilized voxel-based lesion symptom mapping and cross-sectional voxel-based morphometry (VBM) in 52 post-stroke individuals.
Performed longitudinal VBM analysis on 43 individuals with supratentorial lesions at approximately 8 and 15 weeks post-admission.
Correlated motor assessment scores (Fugl-Meyer assessment) with lesion location and GMV changes over time.

Main Results:

Found cross-sectional correlations between motor function and GMV in the ipsilesional cerebellum and contralesional parietal cortex.
Observed longitudinal increases in GMV in the ipsilesional supplementary motor area and cerebellar regions, with a decrease in the ipsilesional thalamus.
Motor recovery significantly correlated with GMV changes in superior and inferior cerebellar zones, with specific correlations for upper-limb and lower-limb function.

Conclusions:

Macrostructural neuroplasticity, particularly within the cerebellum, is associated with individual variations in motor recovery after stroke.
These findings support the hypothesis that cerebellar structural changes contribute to differential motor rehabilitation outcomes.