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Related Experiment Video

Updated: Jul 12, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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[A man with brown discolorations].

Kelly A A Kwa1,2, Kees-Peter de Roos1

  • 1Erasmus Medisch Centrum, afd. Dermatologie, Rotterdam.

Nederlands Tijdschrift Voor Geneeskunde
|October 26, 2023
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Summary
This summary is machine-generated.

Laugier-Hunziker syndrome is a benign condition causing spontaneous brown mouth and hand discolorations. Diagnosis was confirmed via skin biopsy, and no treatment is necessary for this skin disorder.

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Differential diagnosis for oral and hand hyperpigmentation includes genetic syndromes and endocrine disorders.
  • Peutz-Jeghers syndrome and Addison's disease were considered but ruled out based on clinical presentation and prior investigations.

Observation:

  • A 58-year-old male presented with asymptomatic, spontaneous brown macules on the oral mucosa and palmar surfaces.
  • Previous colonoscopy revealed no gastrointestinal polyps, and no systemic symptoms suggestive of Addison's disease were reported.

Findings:

  • Laugier-Hunziker syndrome was diagnosed based on clinical presentation and confirmed by skin biopsy.
  • Histopathological examination supported the diagnosis of Laugier-Hunziker syndrome, a benign lentiginosis.

Implications:

  • Laugier-Hunziker syndrome is a benign condition requiring no specific treatment.
  • Accurate diagnosis prevents unnecessary investigations for other systemic diseases presenting with similar mucocutaneous pigmentation.