A structural foundation for studying chlamydial polymorphic membrane proteins
Abigail M Debrine1,2, P Andrew Karplus2, Daniel D Rockey1
1Department of Biomedical Sciences, Oregon State University , Corvallis, Oregon, USA.
Importance:
Infections by bacteria in the genus Chlamydia cause a range of widespread and potentially debilitating conditions in humans and other animals. We analyzed predicted structures of a family of proteins that are potential vaccine targets found in all Chlamydia spp. Our findings deepen the understanding of protein structure, provide a descriptive framework for discussion of the protein structure, and outline regions of the proteins that may be key targets in host-microbe interactions and anti-chlamydial immunity.
Related Concept Videos
Fluid Mosaic Model
The Fluid Mosaic Model
Bacterial Phylum Chlamydiae
Mechanisms of Membrane Domain Formation
Another mechanism for membrane domain formation involves membrane proteins interacting with...
Multi-pass Transmembrane Proteins and β-barrels
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
Membrane Fluidity


