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Updated: Jul 12, 2025

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
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The development of paranasal sinuses in patients with cystic fibrosis: sinuses volume analysis

Agata Kaluzna-Mlynarczyk1,2, Beata Pucher3, Jakub Sroczynski3

  • 1Department of Pediatric Otolaryngology, Institute of Pediatrics, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572, Poznań, Poland. agata.kaluznamlynarczyk@gmail.com.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|October 26, 2023
PubMed

Insights

Children with cystic fibrosis (CF) show significantly different paranasal sinus development compared to healthy peers. This study highlights CF

Area of Science:

  • Pediatric medicine
  • Respiratory medicine
  • Medical imaging

Background:

  • Cystic fibrosis (CF) is a severe systemic disease impacting patients' lives.
  • CF progression affects airways and paranasal sinuses, but pediatric sinus development in CF is understudied.

Purpose of the Study:

  • To evaluate paranasal sinus development in pediatric CF patients.
  • To compare sinus development in CF children versus a healthy control group.

Main Methods:

  • Computed tomography (CT) scans from 114 CF children and 126 healthy children (aged 0-18 years) were analyzed.
  • Volumes of maxillary, frontal, and sphenoid sinuses were measured and statistically compared between groups.

Main Results:

  • Paranasal sinus volume and development increased with age in both CF and control groups.
  • Statistically significant differences in sinus development were observed between the CF and control groups.

Conclusions:

  • CF significantly impacts paranasal sinus development in children.
  • Findings enhance understanding of CF progression and its influence on quality of life.
  • Results may improve diagnostics and therapy for CF-associated chronic sinusitis.
Abstract

Keywords:
ChildrenCystic fibrosisParanasal sinuses developmentPediatic otorynolaryngologySinuses volume

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