[Clinical pathology of chronic hyperplastic laryngitis. 2. Clinical, morphological and statistical studies with...

Data on 13 different clinical, histological and environmental factors were obtained from 54 patients with hyperplastic laryngitis (HL). They were evaluated by multiple linear factor analysis. HL can be considered to be a complex clinico-morphological entity. Precancerous changes in the larynx were closely correlated with the grade of HL. Etiologically only a weak association with tobacco and alcohol use could be found. The development of the disease was independent of age, sex, nasal function and of other chemical, physical or mechanical factors.