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Experimental Eikenella corrodens endocarditis in rabbits.

S J Badger, T Butler, C K Kim

    Infection and Immunity
    |March 1, 1979
    PubMed
    Summary
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    Eikenella corrodens can cause endocarditis in a rabbit model, forming aortic vegetations even without significant bacteremia. This study demonstrates the bacterium

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Cardiovascular Research

    Background:

    • Eikenella corrodens is associated with human periodontitis.
    • Bacterial endocarditis is a serious infection of the heart valves.
    • A reliable animal model is crucial for studying endocarditis pathogenesis.

    Purpose of the Study:

    • To evaluate Eikenella corrodens as a causative agent of endocarditis.
    • To assess the efficacy of a rabbit model for studying Eikenella corrodens-induced endocarditis.

    Main Methods:

    • Surgically catheterized rabbits were infected intravenously with Eikenella corrodens 1073.
    • Blood cultures, autopsies, and tissue cultures were performed 14 days post-infection.
    • Indirect immunofluorescence staining was used to detect bacteria in vegetations.

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    Main Results:

    • All rabbits developed aortic vegetations, with 52% testing positive for E. corrodens.
    • Bacteremia was infrequent, and mortality was low (2/34 rabbits).
    • E. corrodens was detected in vegetations via immunofluorescence, regardless of culture results.

    Conclusions:

    • Eikenella corrodens is an effective pathogen in the rabbit endocarditis model.
    • The model demonstrates that endocarditis can occur with low-grade bacteremia.
    • This model is suitable for further research into Eikenella corrodens endocarditis.