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Related Experiment Video

Updated: Jul 12, 2025

Detecting Glycogen in Peripheral Blood Mononuclear Cells with Periodic Acid Schiff Staining

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Published on: December 23, 2014

Preordering Periodic Acid-Schiff Staining: A Quality Improvement Study.

Zachary J Wolner^1,2, Danielle E Mustin¹, Benjamin K Stoff^1,2

¹Department of Dermatology, Emory University, Atlanta, GA; and.

The American Journal of Dermatopathology

|October 26, 2023

Summary

Reducing unnecessary Periodic acid-Schiff (PAS) stains in dermatology biopsies can be achieved by refining ordering practices. This quality improvement initiative decreased PAS stain usage without impacting fungal infection identification rates.

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Area of Science:

Dermatopathology
Laboratory Medicine
Quality Improvement

Background:

Periodic acid-Schiff (PAS) stain is an ancillary test in dermatopathology, often used for inflammatory and infectious conditions.
Previous research indicates that clinical suspicion and histopathology are unreliable predictors of PAS positivity.
Current guidelines recommend PAS staining primarily for suspected dermatophyte infections.

Conclusions:

Refining the criteria for ordering PAS stains can effectively reduce unnecessary laboratory utilization.
This quality improvement strategy allows for decreased test ordering without compromising the detection of fungal infections.
The described process serves as a replicable model for other laboratories seeking to optimize PAS stain usage.