Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Pigmentation01:19

Pigmentation

2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin Tumors Associated With Cutaneous HPV Infection.

Journal of cutaneous pathology·2025
Same author

A Solitary Fibrofolliculoma on the Back With a Nevus.

The American Journal of dermatopathology·2025
Same author

Rare Concomitant Langerhans Cell Histiocytosis in a Patient With Folliculotropic Mycosis Fungoides.

Journal of cutaneous pathology·2025
Same author

Dermatologic Lesions with Eosinophilia in the Head and Neck.

Head and neck pathology·2025
Same author

Diagnostic utility of direct immunofluorescence test panels for cutaneous vasculitis: A scoping review.

Journal of cutaneous pathology·2024
Same author

A Call to Improve Medical Education on Skin of Color.

Academic medicine : journal of the Association of American Medical Colleges·2023
Same journal

Herpetic Whitlow in Association With a Cutaneous Infiltrate of Chronic Lymphocytic Leukemia.

The American Journal of dermatopathology·2026
Same journal

Basal Cell Carcinosarcoma with an Osteosarcomatous Component: A Case Report Supporting the Diagnostic Utility of SATB2 and TRAP Immunostaining with a Literature Review of 22 Cases.

The American Journal of dermatopathology·2026
Same journal

Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series.

The American Journal of dermatopathology·2026
Same journal

On the Progression From Early-to Late-Stage Melanoma: A Potential Sequence of Molecular Events Using Data From Droplet Digital PCR and Array Comparative Genomic Hybridization, A Pilot Study.

The American Journal of dermatopathology·2026
Same journal

Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators.

The American Journal of dermatopathology·2026
Same journal

Metastatic Syringocystadenocarcinoma Papilliferum Mimicking Cutaneous Squamous Cell Carcinoma of Unknown Primary in a Young Patient.

The American Journal of dermatopathology·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.8K

Malignant Melanoacanthoma.

Iesha L Ticknor1, David S Cassarino2

  • 1Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA; and.

The American Journal of Dermatopathology
|October 26, 2023
PubMed
Summary
This summary is machine-generated.

Atypical melanoacanthomas can mimic other skin lesions, necessitating biopsy for accurate diagnosis. This case highlights malignant features mimicking squamous cell carcinoma, emphasizing histological evaluation for correct treatment.

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.8K
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
09:52

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

15.9K

Related Experiment Videos

Last Updated: Jul 12, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.8K
A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.8K
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
09:52

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

15.9K

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Melanoacanthomas are benign skin lesions that can resemble other neoplasms.
  • Accurate diagnosis often requires histopathological examination.

Observation:

  • A 25-year-old woman was initially misdiagnosed with an epidermal inclusion cyst.
  • Histological analysis revealed an atypical melanoacanthoma with features suggestive of malignancy.

Findings:

  • The atypical melanoacanthoma exhibited tumor necrosis, marked cytologic atypia, and numerous atypical mitoses.
  • These features were consistent with malignancy, resembling squamous cell carcinoma.

Implications:

  • This case underscores the critical role of biopsy and histological evaluation in diagnosing skin lesions.
  • Atypical presentations of melanoacanthoma can delay diagnosis and appropriate management.