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Related Experiment Video

Updated: Jul 12, 2025

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Environmental interventions reduced repetitive behavior in a mouse model.

Allison R Bechard1, Shannon McElderry1

  • 1SUNY Geneseo, 1 College Circle, Geneseo, NY 14454, USA.

Physiology & Behavior
|October 26, 2023
PubMed
Summary

Environmental enrichment and A2A adenosine receptor agonist treatments reduced repetitive behaviors in mice. These findings suggest potential therapeutic strategies for neurodevelopmental disorders, improving basal ganglia pathway function.

Keywords:
A2A adenosine receptor (A2AR)Autism spectrum disorder (ASD)Environmental enrichment (EE)Ketogenic diet (KD)

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Behavioral Science

Background:

  • Repetitive motor behaviors are a hallmark of neurodevelopmental disorders like autism spectrum disorder.
  • Early-life, non-invasive interventions are sought to ameliorate these behaviors and enhance functioning.

Purpose of the Study:

  • To investigate the impact of environmental enrichment on repetitive circling behavior in mice.
  • To evaluate the efficacy of an A2A adenosine receptor agonist in conjunction with a ketogenic diet in reducing repetitive behaviors.

Main Methods:

  • Experiment 1: Compared repetitive circling in mice reared in standard versus enriched environments.
  • Experiment 2: Administered an A2A adenosine receptor agonist weekly to mice on a ketogenic diet, assessing repetitive behavior.

Main Results:

  • Environmental enrichment significantly reduced repetitive circling behavior in mice.
  • Weekly injections of the A2A adenosine receptor agonist decreased repetitive behavior in mice fed a ketogenic diet.

Conclusions:

  • Both environmental enrichment and pharmacological intervention with an A2A adenosine receptor agonist can effectively reduce repetitive behaviors.
  • These interventions show promise for improving the functioning of the indirect basal ganglia pathway, relevant to neurodevelopmental disorders.