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Assembly-driven protection from hydrolysis as key selective force during chemical evolution.

Rotem Edri1,2, Sarah Fisher1,2, Cesar Menor-Salvan3

  • 1Institute of Chemistry, The Hebrew University of Jerusalem, Israel.

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|October 26, 2023
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Summary

Molecular assembly protected early biopolymers from breaking down, aiding their selection during prebiotic chemical evolution. This recalcitrance was key for the survival of the fittest molecules.

Keywords:
Recalcitranceabiotic chemistrybiopolymerschemical evolutionmolecular evolutionorigins of lifeprebiotic chemistryself-assembly

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Area of Science:

  • Prebiotic chemistry
  • Origin of life studies
  • Biopolymer science

Background:

  • Biopolymer origins are key to understanding early life.
  • Molecular assembly is a common feature in biological systems.
  • Assembly's role in biopolymer stability is not fully understood.

Purpose of the Study:

  • To investigate the influence of molecular assembly on biopolymer hydrolysis rates.
  • To propose a model where assembly-driven stability was crucial for biopolymer selection in prebiotic environments.

Main Methods:

  • Focus on the relationship between molecular assembly and hydrolysis rates in aqueous solutions.
  • Analysis of assembly's impact on the stability of universal biopolymers.

Main Results:

  • Assembly generally attenuates hydrolysis rates, conferring recalcitrance to biopolymers.
  • This protective effect of assembly likely played a role in the selection of stable molecules.

Conclusions:

  • Molecular assembly was a critical factor in the selection and survival of early biopolymers.
  • The interplay between synthesis and hydrolysis kinetics, modulated by assembly, drove molecular enrichment during chemical evolution.