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Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

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Updated: Jul 12, 2025

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

Hydrogel-Based Biosensors for Bacterial Infections.

Xiaoning Sun¹, Chunmei Ding¹, Meng Qin¹

¹College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)

|October 26, 2023

Summary

Hydrogel biosensors offer early bacterial infection diagnosis and treatment. This review covers advancements in pH-sensitive, secretion-sensitive, and surface-contacting hydrogels for point-of-care applications.

Keywords:

bacterial detection bacterial infections biosensors hydrogels theranostics

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Area of Science:

Biomaterials Science
Sensor Technology
Infectious Disease Diagnostics

Background:

Hydrogels possess excellent biodegradability, biocompatibility, and functionalization properties, making them suitable for biosensor development.
Hydrogel biosensors can detect bacterial infections by responding to microenvironmental changes or interacting with bacterial surfaces.
Early diagnosis and treatment of bacterial infections are crucial for effective management and antibiotic stewardship.

Purpose of the Study:

To review recent advancements in hydrogel-based biosensors for bacterial infection detection and treatment.
To discuss hydrogel biosensors that utilize pH changes, bacterial secretions, or direct surface interactions.
To explore hydrogel biosensors enabling simultaneous diagnosis and on-demand treatment for point-of-care applications.

Main Methods:

Review of literature on hydrogel biosensor technologies for bacterial infections.
Categorization of biosensors based on detection mechanisms (pH, enzymes, antigens, surface receptors).
Discussion of integrated diagnostic and therapeutic hydrogel systems.

Main Results:

Hydrogel biosensors show promise for early bacterial infection diagnosis through various sensing mechanisms.
Biosensors responsive to pH, bacterial secretions, and direct surface interactions are presented.
Emerging hydrogel systems offer combined bacteria diagnosis and on-demand treatment capabilities.

Conclusions:

Hydrogel biosensors represent a significant advancement in the early detection and management of bacterial infections.
The development of point-of-care hydrogel biosensors with integrated treatment functions is a key future direction.
Addressing current challenges will further enhance the clinical utility of hydrogel biosensors for infectious diseases.