Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.2K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elucidating the Neuroinflammatory Modulatory Mechanisms of Maixuekang Capsule via Network Pharmacology in Cerebral Ischemia/Reperfusion Injury Rats.

Developmental neurobiology·2026
Same author

Dl-3-n-Butylphthalide Promotes Cortical Angiogenesis via Akt/GSK-3β Signaling in Ischemic Stroke Mice.

CNS neuroscience & therapeutics·2025
Same author

Dl-3-n-Butylphthalide Promotes Neurogenesis in Ischemic Stroke Mice Through Wnt/β-Catenin Signaling Activation and Neurotrophic Factor Production.

Molecular neurobiology·2025
Same author

3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Anisodine hydrobromide injection promotes neural remodeling and recovery after ischemic stroke in mice.

General physiology and biophysics·2024
Same author

Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of <i>I</i><sub>to</sub>, <i>I</i><sub>K,</sub> and <i>I</i><sub>K1</sub> and Inhibition of <i>I</i><sub>Ca</sub><sub>-L</sub> in Rat Ventricular Myocytes.

Journal of the American Heart Association·2024

Related Experiment Video

Updated: Jul 12, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.1K

Th17 Cells and IL-17A in Ischemic Stroke.

Jingjing Wang1, Yuxiao Gao1, Yujia Yuan1

  • 1Department of Neurology, Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, 050000, Hebei, China.

Molecular Neurobiology
|October 26, 2023
PubMed
Summary

T helper 17 (Th17) cells and their cytokine interleukin-17A (IL-17A) are crucial in ischemic stroke. Targeting these may offer new therapeutic strategies for stroke recovery and treatment.

Keywords:
ImmunomodulationInterleukin-17AIschemic strokeNeuroinflammationTh17 cells

More Related Videos

Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.6K
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

15.7K

Related Experiment Videos

Last Updated: Jul 12, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.1K
Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.6K
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

15.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Ischemic stroke involves complex neurological injury and repair processes.
  • CD4+ T helper (Th) cells, including Th17 cells, significantly influence inflammation during stroke onset and recovery.
  • Th17 cells produce interleukin-17A (IL-17A), a pro-inflammatory cytokine with implications in stroke.

Purpose of the Study:

  • To review the mechanisms of Th17 cells and IL-17A in ischemic stroke.
  • To explore their role in stroke pathogenesis, secondary damage, and repair.
  • To discuss the progress in targeted therapies for stroke involving Th17 and IL-17A.

Main Methods:

  • Literature review of experimental research on Th17 cells and IL-17A in ischemic stroke.
  • Analysis of the regulatory mechanisms of Th17 cell differentiation and function.
  • Synthesis of findings on the impact of Th17/IL-17A in stroke models and clinical observations.

Main Results:

  • Th17 cells and IL-17A are implicated in promoting atherosclerosis, a key factor in stroke pathogenesis.
  • These factors contribute to secondary neurological damage following ischemic events.
  • Evidence suggests Th17 cells and IL-17A also play a role in regulating post-stroke repair mechanisms.

Conclusions:

  • Th17 cells and IL-17A are critical players in the multifaceted landscape of ischemic stroke.
  • Their dual role in damage and repair presents a complex therapeutic target.
  • Targeting Th17 and IL-17A pathways holds potential for novel stroke treatment strategies.