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Updated: Jul 12, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Th17 Cells and IL-17A in Ischemic Stroke

Jingjing Wang1, Yuxiao Gao1, Yujia Yuan1

  • 1Department of Neurology, Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, 050000, Hebei, China.

Molecular Neurobiology
|October 26, 2023
PubMed

The neurological injury and repair mechanisms after ischemic stroke are complex. The inflammatory response is present throughout stroke onset and functional recovery, in which CD4 + T helper(Th) cells play a non-negligible role. Th17 cells, differentiated from CD4 + Th cells, are regulated by various extracellular signals, transcription factors, RNA, and post-translational modifications. Th17 cells specifically produce interleukin-17A(IL-17A), which has been reported to have pro-inflammatory effects in many studies. Recently, experimental researches showed that Th17 cells and IL-17A play an important role in promoting stroke pathogenesis (atherosclerosis), inducing secondary damage after stroke, and regulating post-stroke repair. This makes Th17 and IL-17A a possible target for the treatment of stroke. In this paper, we review the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.

Keywords:
ImmunomodulationInterleukin-17AIschemic strokeNeuroinflammationTh17 cells

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