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Updated: Jul 12, 2025
08:20
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
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A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT)
Dongqing Yan1, Gengqiu Liu2, Yin Yin2
1Department of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, 628 Zhenyuan Rd, Shenzhen, 518107, China. yandq8@mail.sysu.edu.cn.
Sleep & Breathing = Schlaf & Atmung
|October 26, 2023
Summary
Napping may reduce the risk of deep vein thrombosis (DVT). This study used genetic data to explore the link between napping and DVT, finding a potential causal relationship for decreased DVT incidence.
Area of Science:
- Genetics
- Epidemiology
- Internal Medicine
Background:
- Napping is a common practice for rest.
- Previous studies suggest links between napping and various health outcomes.
- The relationship between napping and deep vein thrombosis (DVT) requires investigation.
Purpose of the Study:
- To investigate the potential causal effect of napping on the development of deep vein thrombosis (DVT).
Main Methods:
- Utilized a two-sample Mendelian randomization (MR) approach.
- Employed summary statistics from genome-wide association studies (GWAS) for napping (UK Biobank) and DVT (FinnGen Biobank).
- Used 86 single nucleotide polymorphisms (SNPs) strongly associated with napping as instrumental variables, applying Inverse Variance Weighting (IVW), MR-Egger, weighted median, and weighted mode methods.
Main Results:
- Consistent association observed between napping and a reduced risk of DVT (e.g., IVW: OR 0.508, 95% CI 0.280-0.921).
- No significant evidence of genetic pleiotropy affecting the napping-DVT relationship was found (MR-Egger intercept P = 0.525).
Conclusions:
- The Mendelian randomization study suggests a potential causal link between napping and a reduced incidence of DVT.
- Findings indicate that napping may be associated with a lower risk of developing deep vein thrombosis.
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