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Updated: Jul 12, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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The (Pro)renin Receptor - A Regulatory Nodal Point in Disease Networks

Heiko Funke-Kaiser1, Thomas Unger2

  • 1CCR Pharma (CCRP) Therapeutics, Berlin, Germany.

Current Drug Targets
|October 27, 2023
PubMed

Insights

Inhibiting the (pro)renin receptor, or (P)RR, shows therapeutic promise across diseases. Recent structural insights using AlphaFold link (P)RR interactions to disease, guiding new drug discovery for this target.

Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology
  • Structural Biology

Background:

  • The (pro)renin receptor [(P)RR] is implicated in various diseases, including cardiorenal and oncological conditions.
  • Understanding (P)RR's protein-protein interactions is crucial for elucidating its pathological roles.
  • Existing therapeutic strategies focus on inhibiting (P)RR activity.

Approach:

  • This review highlights recent structural studies of the (P)RR using AlphaFold.
  • It examines the direct protein-protein interaction partners of the (P)RR.
  • The review discusses antibody- and small molecule-based approaches for (P)RR inhibition.

Key Points:

  • The 3D structure of the (P)RR, determined by AlphaFold, provides mechanistic links between protein interactions and disease pathology.
  • Detailed structural insights into the (P)RR and its interaction domains are essential for rational drug design.
  • The (P)RR is involved in a wide array of distinct disease models.

Conclusions:

  • Structural biology advancements, particularly AlphaFold, are pivotal for understanding (P)RR function and disease involvement.
  • Targeting the (P)RR offers a promising therapeutic avenue for multiple diseases.
  • Further research into (P)RR structure-function relationships will accelerate the development of novel inhibitors.
Keywords:
(Pro)renin receptor (P)RRAlphaFoldcardiorenal.drug targetoncologyprotein-protein interaction partners

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