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Pyrazolo - Pyrimidines as Targeted Anticancer Scaffolds - A Comprehensive Review
Kesavamoorthy Kandhasamy1, Remya Ramachandran Surajambika1, Pradeep Kumar Velayudham1
1Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai- 600 097, India.
Medicinal Chemistry (Shariqah (United Arab Emirates))
|October 27, 2023
Summary
This review explores pyrazole and pyrimidine hybrids as promising anticancer agents. These compounds show potential for targeted cancer therapy, offering new hope against drug resistance.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Pharmacology
Background:
- Cancer is a leading global cause of death, resulting in 10 million deaths annually.
- Current cancer treatments often fail due to drug resistance and multidrug resistance.
Purpose of the Study:
- To comprehensively review pyrazole and pyrimidine hybrids as potential anticancer agents.
- To analyze the efficiency and structural aspects of these fused heterocyclic compounds.
Main Methods:
- Literature review of over 60 research works in the field.
- Discussion of biological data and structure-activity relationships of pyrazolopyrimidine compounds.
Main Results:
- Pyrazolo-pyrimidines identified as effective targeted anticancer agents.
- These compounds demonstrate efficacy against multiple cancer targets.
Conclusions:
- Pyrazolo-pyrimidine scaffolds are valuable for designing novel anticancer drugs.
- This review aids researchers in developing targeted cancer therapies.
Keywords:
Canceranti-cancer agentsheterocyclemulti-drug resistantpyrazolopyrimidinepyrimidine hybrids.More Related Videos
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