Related Experiment Video
Updated: Jul 12, 2025
06:05
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
Published on: July 14, 2023
1.0K
Injective Programmable Proanthocyanidin-Coordinated Zinc-Based Composite Hydrogel for Infected Bone Repair
Yue Wang1,2, Yitao Zhao1,2, Shiyuan Ma1,2
1Department of Histology and Embryology, NMPA Key Laboratory for Safety Evaluation of Cosmetics, School of Basic Medical Sciences, Guangzhou, 510515, P. R. China.
Advanced Healthcare Materials
|October 27, 2023
Summary
New injectable hydrogels combine infection control and bone healing. These proanthocyanidin (PC)-coordinated zinc-based composite hydrogels (ipPZCHs) release antimicrobial ions and promote osteogenesis in infected bone defects.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Infectious Disease Research
Background:
- Treating infected bone defects requires simultaneous infection control and bone regeneration.
- Existing methods face challenges in integrating these dual functions effectively.
- Developing advanced biomaterials is crucial for overcoming these limitations.
Purpose of the Study:
- To develop injectable, programmable composite hydrogels for infected bone repair.
- To create a system that integrates antimicrobial properties with osteogenesis promotion.
- To investigate the reactive oxygen species (ROS)-responsive behavior of the hydrogel system.
Main Methods:
- Synthesized proanthocyanidin (PC)-coordinated zinc oxide (ZnO) microspheres.
- Composited PC-coordinated ZnO with thioether-grafted sodium alginate (TSA) to form injectable hydrogels (ipPZCHs).
- Utilized calcium chloride (CaCl2) for crosslinking and studied ROS-responsive degradation and ion release.
Main Results:
- ipPZCHs demonstrated significant antimicrobial activity against bone infections.
- The hydrogels exhibited ROS-responsive disintegration, releasing antimicrobial zinc (Zn2+) and silver (Ag+) ions.
- Degradation of ipPZCHs facilitated bone ingrowth, while released PC enhanced immunomodulatory and osteoinductive properties.
Conclusions:
- The developed ipPZCHs offer a programmable and self-adaptive approach for infected bone repair.
- The synergistic action of antimicrobial ion release, ROS-responsive degradation, and enhanced osteogenesis promotes effective bone healing.
- This strategy holds promise for treating challenging bone infections and defects.
