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Updated: Jul 12, 2025

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
From mental strain to gut pain: A brain-gut pathway transducing psychological stress to intestinal inflammation
Kai Markus Schneider1,2, Niklas Blank1, Christoph A Thaiss1
1Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract:
Psychological stress can trigger inflammatory bowel disease (IBD) flares, but the molecular mechanisms have remained unclear. We recently discovered an unexpected function of the enteric nervous system as a relay between stress signals from the brain and intestinal inflammation. Our findings highlight targeting stress-induced signaling networks as a possible new pillar in the clinical management of IBD.
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