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Related Concept Videos

Pericarditis I: Introduction01:22

Pericarditis I: Introduction

11
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
11
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

11
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
11
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

18
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
18
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

15
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
15
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

12
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
12
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

8
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
8

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Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

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Voriconazole-Induced Periostitis: A Case Report.

Tristan D Cooper-Roth1, Caleb R Boehler1, Stefano J Natali1

  • 1Radiology, University of Arizona College of Medicine-Tucson, Tucson, USA.

Cureus
|October 27, 2023
PubMed
Summary

Voriconazole-induced periostitis (VIP) is a rare side effect causing bone pain and fractures in immunocompromised patients. Consider VIP in patients with a history of organ transplant and long-term voriconazole use.

Keywords:
msk radiologymusculoskeletal radiologyperiostitisvoriconazole therapyvoriconazole toxicity

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Area of Science:

  • Pharmacology
  • Orthopedics
  • Rheumatology

Background:

  • Voriconazole-induced periostitis (VIP) is an uncommon adverse effect of prolonged voriconazole therapy.
  • It primarily affects immunosuppressed patients, often those with a history of solid organ transplantation.
  • Clinical manifestations include bone pain, fragility, and elevated alkaline phosphatase (ALP).

Observation:

  • A 72-year-old immunocompromised female presented with a comminuted intertrochanteric fracture after a ground-level fall.
  • The patient was undergoing long-term antifungal therapy with voriconazole.
  • Radiographic features suggested periostitis, prompting consideration of VIP.

Findings:

  • Voriconazole-induced periostitis (VIP) should be considered in the differential diagnosis for patients presenting with bone pain and/or fractures.
  • Radiographic findings of periostitis in conjunction with a history of organ transplant and long-term voriconazole use are key indicators.
  • Diagnosis is confirmed by excluding underlying rheumatologic diseases and reviewing medication history.

Implications:

  • Early recognition of VIP can prevent misdiagnosis and inappropriate treatment for fractures.
  • Awareness among clinicians is crucial for managing patients on long-term voriconazole therapy.
  • This case highlights the importance of a thorough medication review in patients with unexplained bone pathology.