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The predictive value of liver tests for the presence of liver metastases
Alexandra V Kimchy1, Harjit Singh1, Esha Parikh2
1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, USA.
Aim:
To analyze the predictive value of biochemical liver tests in patients with malignant melanoma, breast, colorectal or lung cancers at the time of diagnosis of liver metastases.
Methods:
A retrospective review of patients with the above-mentioned solid tumors at MedStar Georgetown University Hospital from 2016-2020.
Results:
The highest optimal cutoff according to sensitivity and specificity for the presence of liver metastases was for AST ≥1.5 × ULN for melanoma, lung, and breast cancers and ≥2 × ULN for colorectal cancer, ALT ≥1.25 × ULN for melanoma, breast and colorectal cancers and ≥1.5 × ULN for lung cancer, and ALP ≥1.5 × ULN for melanoma, breast and colorectal cancers.
Conclusion:
Using thresholds of liver enzymes above the ULN may improve the diagnostic accuracy for the presence of liver metastases.
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