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Potential biomarkers in Japanese encephalitis from different hosts and geographical locations

Sain Ziaullah M1, Mohammad Azhar Kamal2, Mohiuddin Khan Warsi3,4

  • 1Department of Microbiology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah KSA 21589.

Bioinformation
|October 27, 2023
PubMed

Insights

Japanese encephalitis (JE) is a severe mosquito-borne virus. Genomic analysis reveals JE virus strains share significant similarities, with minimal genetic variation observed across different global samples.

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • Japanese encephalitis (JE) is a severe mosquito-borne flavivirus causing significant mortality and neurological sequelae.
  • The JE virus has a 10.98 kb genome, including coding DNA sequences (CDS) and mature peptides.
  • Current treatments exist, but there is no known cure for JE, highlighting the need for further research.

Purpose of the Study:

  • To comparatively analyze genomic annotations of the JE virus to understand its evolutionary aspects.
  • To investigate genetic variations and similarities among JE virus strains from different geographical locations and hosts.

Main Methods:

  • Utilized 29 genomic sequences of the JE virus from diverse global origins and hosts.
  • Performed extensive single nucleotide polymorphism (SNP) analysis.
  • Conducted repeat and polymorphism analyses on JE virus genomes.

Main Results:

  • Identified minimal genetic variation, with most JE virus genomes showing high similarity.
  • The KF907505.1 strain from Taiwan exhibited only three SNPs, comparable to Indian strains.
  • Repeat and polymorphism analyses indicated a general tendency for genome similarity across JE sequences.

Conclusions:

  • The JE virus genome demonstrates remarkable conservation across different geographical regions and hosts.
  • Understanding genomic similarities can inform strategies for JE virus surveillance and control.
  • Further research into the evolutionary dynamics of JE virus is warranted.
Keywords:
Japanese encephalitis virusSingle Nucleotide Polymorphism (SNPs)phobosphylogenomicstranscription factors

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