Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

6.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
6.4K
Regulation of Food Intake01:30

Regulation of Food Intake

248
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
248
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of MicroRNA-200a/b/c in the Mediobasal Hypothalamic Nuclei with Aging.

MicroRNA (Shariqah, United Arab Emirates)·2023
Same author

Ontogenetic Changes in the Expression of the Lin28 Protein in the Rat Hypothalamic Tuberal Nuclei.

International journal of molecular sciences·2022
Same author

Sympathetic innervation of the development, maturity, and aging of the gastrointestinal tract.

Anatomical record (Hoboken, N.J. : 2007)·2022
Same author

Postnatal development of the enteric neurons expressing neuronal nitric oxide synthase.

Anatomical record (Hoboken, N.J. : 2007)·2022
Same author

Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.

Anatomical record (Hoboken, N.J. : 2007)·2020
Same author

Development of Calbindin- and Calretinin-Immunopositive Neurons in the Enteric Ganglia of Rats.

Cellular and molecular neurobiology·2016

Related Experiment Video

Updated: Jul 12, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.2K

Changes of Signaling Pathways in Hypothalamic Neurons with Aging.

Petr M Masliukov1

  • 1Department Normal Physiology, Yaroslavl State Medical University, ul. Revoliucionnaya 5, 150000 Yaroslavl, Russia.

Current Issues in Molecular Biology
|October 27, 2023
PubMed
Summary

Aging disrupts hypothalamic signaling pathways crucial for autonomic and endocrine functions. This review details changes in key pathways like insulin/IGF-1, PI3K/AKT/mTOR, and MAPK during hypothalamic aging.

Keywords:
aginghypothalamussignaling pathways

More Related Videos

Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.6K
Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons
13:24

Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons

Published on: December 1, 2015

8.4K

Related Experiment Videos

Last Updated: Jul 12, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.2K
Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.6K
Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons
13:24

Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons

Published on: December 1, 2015

8.4K

Area of Science:

  • Neuroscience
  • Aging Research
  • Endocrinology

Background:

  • The hypothalamus regulates vital autonomic and endocrine functions.
  • Hypothalamic dysfunction is implicated in the aging process.
  • Intracellular signaling pathways are critical for hypothalamic function.

Purpose of the Study:

  • To review current understanding of intracellular signaling pathway alterations in the aging hypothalamus.
  • To focus on key pathways including insulin/IGF-1, PI3K/AKT/mTOR, MAPK, JAK/STAT, AMPK, NF-ĸB, and NO.

Main Methods:

  • Literature review of studies on hypothalamic aging and intracellular signaling.
  • Synthesis of findings on pathway dysregulation in the aging hypothalamus.

Main Results:

  • Aging is associated with disturbed intracellular signaling in the hypothalamus.
  • Specific pathways affected include insulin/IGF-1, PI3K/AKT/mTOR, MAPK, JAK/STAT, AMPK, NF-ĸB, and NO.
  • These changes contribute to the aging process within the hypothalamus.

Conclusions:

  • Intracellular signaling pathway dysregulation is a hallmark of hypothalamic aging.
  • Understanding these changes is crucial for addressing age-related hypothalamic dysfunction.
  • Further research is needed to explore therapeutic interventions targeting these pathways.