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Changes of Signaling Pathways in Hypothalamic Neurons with Aging
1Department Normal Physiology, Yaroslavl State Medical University, ul. Revoliucionnaya 5, 150000 Yaroslavl, Russia.
Current Issues in Molecular Biology
|October 27, 2023
Summary
Aging disrupts hypothalamic signaling pathways crucial for autonomic and endocrine functions. This review details changes in key pathways like insulin/IGF-1, PI3K/AKT/mTOR, and MAPK during hypothalamic aging.
Area of Science:
- Neuroscience
- Aging Research
- Endocrinology
Background:
- The hypothalamus regulates vital autonomic and endocrine functions.
- Hypothalamic dysfunction is implicated in the aging process.
- Intracellular signaling pathways are critical for hypothalamic function.
Purpose of the Study:
- To review current understanding of intracellular signaling pathway alterations in the aging hypothalamus.
- To focus on key pathways including insulin/IGF-1, PI3K/AKT/mTOR, MAPK, JAK/STAT, AMPK, NF-ĸB, and NO.
Main Methods:
- Literature review of studies on hypothalamic aging and intracellular signaling.
- Synthesis of findings on pathway dysregulation in the aging hypothalamus.
Main Results:
- Aging is associated with disturbed intracellular signaling in the hypothalamus.
- Specific pathways affected include insulin/IGF-1, PI3K/AKT/mTOR, MAPK, JAK/STAT, AMPK, NF-ĸB, and NO.
- These changes contribute to the aging process within the hypothalamus.
Conclusions:
- Intracellular signaling pathway dysregulation is a hallmark of hypothalamic aging.
- Understanding these changes is crucial for addressing age-related hypothalamic dysfunction.
- Further research is needed to explore therapeutic interventions targeting these pathways.
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