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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Immune Checkpoints in Solid Organ Transplantation.

Arnaud Del Bello^1,2,3, Emmanuel Treiner^3,4,5

¹Department of Nephrology, University Hospital of Toulouse, 31400 Toulouse, France.

|October 27, 2023

Summary

This summary is machine-generated.

Achieving stable immune tolerance in solid organ transplantation (SOT) is crucial. This review explores immune checkpoints (ICs) and their potential to induce graft acceptance, moving beyond current immunosuppression toxicities.

Keywords:

immune checkpoints immunotherapy organ transplantation tolerance

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

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Published on: May 2, 2013

Area of Science:

Immunology
Transplantation Science
Oncology Therapeutics

Background:

Solid organ transplantation (SOT) requires lifelong immunosuppression, posing risks of toxicity and treatment adaptation challenges.
Current immunosuppressive strategies balance excessive versus insufficient immune suppression, impacting graft acceptance.
Immune checkpoints (ICs) are co-receptors regulating immune responses; their dysregulation contributes to autoimmunity and transplant rejection.

Purpose of the Study:

To review the role of immune checkpoints (ICs) in solid organ transplantation (SOT).
To explore the potential of modulating ICs for achieving stable immune tolerance towards grafted organs.
To discuss the influence of existing immunosuppressive drugs on IC function.

Main Methods:

Literature review of existing studies on ICs in SOT.
Analysis of the role of ICs in graft acceptance and immune tolerance.
Discussion of therapeutic strategies involving IC modulation.

Main Results:

Immune checkpoints play a critical role in regulating immune responses relevant to SOT.
Modulating ICs offers a potential strategy for inducing specific hypo-responsiveness to allo-antigens.
Current immunosuppressive medications may impact IC function, requiring further investigation.

Conclusions:

Targeting immune checkpoints presents a promising avenue for improving SOT outcomes.
Developing therapies to subvert ICs could lead to stable graft acceptance without chronic immunosuppression.
Further research is needed to understand the interplay between immunosuppressants and ICs in transplantation.