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Streptococcus pyogenes Lineage ST62/emm87: The International Spread of This Potentially Invasive Lineage

Caroline Lopes Martini1, Deborah Nascimento Santos Silva1, Alice Slotfeldt Viana1

  • 1Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.

Antibiotics (Basel, Switzerland)
|October 27, 2023
PubMed

Insights

The ST62/emm87 lineage of Streptococcus pyogenes is a globally spreading cause of invasive infections. This study reveals its shared virulence factors with common emm types, highlighting its underestimated threat in severe diseases.

Area of Science:

  • Genomics and Phylogenomics
  • Microbiology
  • Infectious Diseases

Background:

  • Streptococcus pyogenes causes diverse infections, from pharyngitis to necrotizing fasciitis.
  • The ST62/emm87 lineage is frequently isolated from invasive infections and implicated in outbreaks.
  • Limited genomic and phylogenomic data exist for the ST62/emm87 lineage, leaving virulence and resistance profiles largely unknown.

Purpose of the Study:

  • To conduct comparative genomic and phylogenomic analyses of the ST62/emm87 Streptococcus pyogenes lineage.
  • To evaluate the virulence and antimicrobial susceptibility profiles of this lineage.
  • To understand the genetic relationships and evolutionary traits of ST62/emm87 strains.

Main Methods:

  • Genomic and phylogenomic analyses were performed on ST62/emm87 Streptococcus pyogenes strains.
  • Virulence and antimicrobial resistance profiles were evaluated.
  • International and Brazilian isolates were included in the study.

Main Results:

  • The ST62/emm87 lineage is internationally distributed and associated with invasive bacterial infections and outbreaks.
  • These strains share significant virulence profiles with highly prevalent emm types (emm1, emm3, emm12, emm69).
  • The study characterized the genomic and phylogenomic features of this globally spreading lineage.

Conclusions:

  • The ST62/emm87 lineage of Streptococcus pyogenes is a significant global pathogen.
  • Its shared virulence factors with common emm types warrant attention.
  • The increasing prevalence of ST62/emm87 in severe S. pyogenes diseases should not be underestimated.
Keywords:
ST62Streptococcus pyogenesemm87flesh-eating diseasesscarlet fever

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