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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
500

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Related Experiment Video

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Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
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Mammalian Models in Alzheimer's Research: An Update.

Himadri Sharma1, Keun-A Chang2, John Hulme1

  • 1Department of Bionano Technology, Gachon Bionano Research Institute, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 461-701, Gyeonggi-do, Republic of Korea.

Cells
|October 27, 2023
PubMed
Summary

Alzheimer's disease (AD) research is advancing with new mammalian models that better mimic human disease complexity. These models offer improved insights into AD pathogenesis compared to older, limited approaches.

Keywords:
Alzheimer’s Diseasemouse modelsnon-human primatetauβ-amyloid

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Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting over 50 million people globally.
  • Current therapeutic strategies for AD have faced limitations, partly due to insufficient animal models.
  • There is a critical need for more accurate models that reflect human AD's complexity.

Purpose of the Study:

  • To review current mammalian models used in Alzheimer's disease (AD) research.
  • To discuss the advancements and limitations of prominent transgenic models.
  • To explore emerging models that better represent human genetic heterogeneity and mixed pathologies in AD.

Main Methods:

  • Review of recent literature on transgenic mammalian models for AD research.
  • Analysis of prominent and emerging models, focusing on their ability to recapitulate AD pathogenesis.
  • Discussion of model advantages, limitations, and applications in understanding disease mechanisms.

Main Results:

  • Established transgenic models offer insights but have limitations in fully capturing AD complexity.
  • Emerging models show promise in reflecting genetic diversity and mixed pathologies seen in human AD.
  • These advanced models are crucial for developing more effective AD therapies.

Conclusions:

  • Mammalian models are essential tools for understanding Alzheimer's disease (AD) pathogenesis.
  • Newer models are improving the translation of research findings to clinical applications.
  • Continued development of sophisticated models is key to advancing AD therapeutics and treatments.