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Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Integrated Meta-Omics Analysis Unveils the Pathways Modulating Tumorigenesis and Proliferation in High-Grade
Deeptarup Biswas1, Ankit Halder1, Abhilash Barpanda1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Cells
|October 27, 2023
Summary
High-grade meningioma tumorigenesis involves extracellular matrix organization and integrin signaling. Inhibiting integrin-linked kinase (ILK) suppressed tumor cell proliferation and induced apoptosis.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Genomics
Background:
- Meningioma is a common primary central nervous system (CNS) tumor, with limited treatment options beyond surgery.
- Existing research has identified potential markers and pathways, but comprehensive data integration is needed for deeper pathobiology understanding.
Conclusions:
- Integrated omics data and pathway analysis provide mechanistic insights into high-grade meningioma pathobiology.
- EMO and integrin signaling pathways are critical in meningioma development.
- ILK inhibition presents a potential therapeutic strategy for high-grade meningioma by targeting proliferation and metastasis.
Keywords:
apoptosisextracellular matrix organization (EMO)integrated-omicsintegrin-linked kinase (ILK)meningiomameta-analysisproteomicstranscriptomicsMore Related Videos
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