Related Experiment Video

Updated: Jul 12, 2025

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Tumor Angiocrine Signaling: Novel Targeting Opportunity in Cancer

Victor Oginga Oria1, Janine Terra Erler1

  • 1Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.

Cells
|October 27, 2023
PubMed

Insights

Endothelial cells actively shape tumors by secreting angiocrine factors, influencing cancer progression, metastasis, and resistance to therapy. Understanding this signaling is key to developing new cancer treatments.

Area of Science:

  • Oncology
  • Cell Biology
  • Vascular Biology

Background:

  • The vascular endothelium provides oxygen and nutrients and supports cancer progression via angiogenesis.
  • Resistance to anti-angiogenic therapies poses a significant challenge in cancer treatment.
  • Endothelial cells are increasingly recognized as active participants in the tumor microenvironment, beyond just angiogenesis.

Purpose of the Study:

  • To review the multifaceted role of angiocrine signaling in cancer.
  • To highlight how endothelial cells influence tumor progression, metastasis, and therapy resistance.
  • To underscore the importance of understanding endothelium signaling for novel therapeutic strategies.

Main Methods:

  • Literature review of recent research on endothelial cells and cancer.
  • Analysis of angiocrine factors secreted by endothelial cells.
  • Synthesis of current knowledge on endothelium-derived signaling in tumorigenesis.

Main Results:

  • Endothelial cells secrete angiocrine factors (cytokines, growth factors, chemokines) that instruct the tumor microenvironment.
  • Angiocrine signaling is implicated in distant metastasis, tumor dormancy, and pre-metastatic niche formation.
  • Endothelial cell signaling contributes to immune evasion and resistance to cancer therapies.

Conclusions:

  • Angiocrine signaling plays a critical and complex role in multiple facets of cancer progression.
  • Targeting endothelial cell-derived signals offers potential for overcoming therapeutic resistance and improving cancer treatment outcomes.
  • Further research into endothelium signaling is crucial for advancing oncology therapeutics.
Keywords:
angiocrine factorsangiocrine signalingendothelium

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