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Development of Solid Lipid Nanoparticles for Controlled Amiodarone Delivery.

Andreea Creteanu¹, Gabriela Lisa², Cornelia Vasile³

¹Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.

Methods and Protocols

|October 27, 2023

Summary

This study developed amiodarone-loaded solid lipid nanoparticles (AMD-SLNs) to enhance the solubility and oral delivery of amiodarone hydrochloride. The P5 formulation demonstrated optimal properties for controlled drug release.

Keywords:

amiodarone controlled delivery solid lipid nanoparticles

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Area of Science:

Pharmaceutical Nanotechnology
Drug Delivery Systems

Background:

Solid lipid nanoparticles (SLNs) are effective lipid-based nanocarriers for drug delivery.
Amiodarone hydrochloride, an antiarrhythmic drug, exhibits poor oral absorption due to low solubility and high permeability.
Improving amiodarone's solubility is crucial for effective therapeutic outcomes.

Purpose of the Study:

To enhance the solubility and oral bioavailability of amiodarone hydrochloride.
To develop and characterize amiodarone-loaded solid lipid nanoparticles (AMD-SLNs) using Compritol® 888 ATO and Transcutol®.
To evaluate the pharmaco-technical properties and in vitro dissolution of the developed AMD-SLNs.

Main Methods:

Hot homogenization followed by ultrasonication was employed to prepare AMD-SLNs.
Formulations were characterized for size, polydispersity index, zeta potential, entrapment efficiency, and drug loading.
Advanced techniques including SEM, FTIR, NIR, TGA, and DSC were used for comprehensive analysis.
In vitro dissolution studies were conducted to assess drug release profiles.

Main Results:

Six types of AMD-SLNs were successfully prepared with varying sonication parameters.
The P5 formulation exhibited optimal pharmaco-technical characteristics.
SEM, FTIR, NIR, TGA, and DSC analyses confirmed the successful encapsulation and stability of amiodarone within the SLNs.
In vitro dissolution tests indicated a controlled release pattern for amiodarone from the P5 formulation.

Conclusions:

The developed AMD-SLNs, particularly the P5 formulation, show significant potential for improving amiodarone hydrochloride's oral delivery.
Solid lipid nanoparticles offer a promising platform for enhancing the solubility and controlled release of poorly soluble drugs like amiodarone.
Further investigation into oral pharmaceutical products utilizing these optimized AMD-SLNs is warranted.