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Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Updated: Jun 14, 2026

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Stimuli-Responsive Hydrogels for Protein Delivery.

Rafaela Malta¹, Ana Camila Marques^2,3, Paulo Cardoso da Costa^2,3

¹CeNTI-Centre for Nanotechnology and Smart Materials, Rua Fernando Mesquita, 2785, 4760-034 Vila Nova de Famalicão, Portugal.

Gels (Basel, Switzerland)

|October 27, 2023

Summary

Stimuli-responsive hydrogels offer a promising solution for delivering therapeutic proteins and peptides. These advanced materials protect biomolecules and enable controlled release, overcoming key challenges in drug delivery.

Keywords:

peptides protein delivery proteins stimuli-responsive hydrogels

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Last Updated: Jun 14, 2026

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Published on: September 15, 2017

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Published on: January 24, 2025

Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Proteins and peptides show therapeutic potential but face delivery challenges due to physiochemical properties.
Hydrogels, as hydrophilic polymeric networks, are biocompatible and possess porous structures ideal for biomolecule transport and protection.
Stimuli-responsive hydrogels offer tunable release profiles by undergoing transitions in response to environmental cues.

Purpose of the Study:

To review the application of stimuli-responsive hydrogels for protein and peptide delivery.
To provide an overview of therapeutic proteins and the types of stimuli-responsive polymers used in drug delivery.

Main Methods:

Literature review focusing on stimuli-responsive hydrogels in protein and peptide delivery.
Analysis of hydrogel properties, including biocompatibility, porous structure, and protective effects.
Discussion of stimuli-responsive polymer types and their role in controlled release.

Main Results:

Hydrogels serve as effective carriers for proteins and peptides, protecting them from degradation.
Stimuli-responsive hydrogels enable controlled release of therapeutic biomolecules.
Various stimuli-responsive polymers can be utilized to tailor drug release kinetics.

Conclusions:

Stimuli-responsive hydrogels are highly promising for advanced protein and peptide drug delivery systems.
Their ability to protect biomolecules and provide controlled release addresses critical challenges in therapeutic applications.